Multiple Sequence Alignment Based on Profile Alignment of Intermediate Sequences

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Multiple Sequence Alignment Based on Profile Alignment of Intermediate Sequences

Despite considerable efforts, it remains difficult to obtain accurate multiple sequence alignments. By using additional hits from database search of the input sequences, a few strategies have been proposed to significantly improve alignment accuracy, including the construction of profiles from the hits while performing profile alignment, the inclusion of high scoring hits into the input sequenc...

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Multiple sequence alignment (MSA) has been one of the most important problems in bioinformatics for more decades and it is still heavily examined by many mathematicians and biologists. However, mostly because of the practical motivation of this problem, the research on this topic is focused on aligning long sequences. It is understandable, since the sequences that need to be aligned (usually DN...

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ژورنال

عنوان ژورنال: Journal of Computational Biology

سال: 2008

ISSN: 1066-5277,1557-8666

DOI: 10.1089/cmb.2007.0132