Multiple Sequence Alignment Based on Profile Alignment of Intermediate Sequences
نویسندگان
چکیده
منابع مشابه
Multiple Sequence Alignment Based on Profile Alignment of Intermediate Sequences
Despite considerable efforts, it remains difficult to obtain accurate multiple sequence alignments. By using additional hits from database search of the input sequences, a few strategies have been proposed to significantly improve alignment accuracy, including the construction of profiles from the hits while performing profile alignment, the inclusion of high scoring hits into the input sequenc...
متن کاملMultiple Sequence Alignment Multiple Sequence Alignment
An algorithm for progressive multiple alignment of sequences with insertions " , 1. Introduction The problem of sequence alignment is to find the patterns of sequence conservation and similarity between pairs or sets of given sequences. In biological contexts, similarity between biological sequences usually amounts to either functional or structural similarities or divergence from a common ance...
متن کاملMultiple sequence alignment for short sequences
Multiple sequence alignment (MSA) has been one of the most important problems in bioinformatics for more decades and it is still heavily examined by many mathematicians and biologists. However, mostly because of the practical motivation of this problem, the research on this topic is focused on aligning long sequences. It is understandable, since the sequences that need to be aligned (usually DN...
متن کاملMultiple Sequence Alignment Based on Set Covers
We introduce a new heuristic for the multiple alignment of a set of sequences. The heuristic is based on a set cover of the residue alphabet of the sequences, and also on the determination of a significant set of blocks comprising subsequences of the sequences to be aligned. These blocks are obtained with the aid of a new data structure, called a suffix-set tree, which is constructed from the i...
متن کاملSegment-based multiple sequence alignment
MOTIVATION Many multiple sequence alignment tools have been developed in the past, progressing either in speed or alignment accuracy. Given the importance and wide-spread use of alignment tools, progress in both categories is a contribution to the community and has driven research in the field so far. RESULTS We introduce a graph-based extension to the consistency-based, progressive alignment...
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ژورنال
عنوان ژورنال: Journal of Computational Biology
سال: 2008
ISSN: 1066-5277,1557-8666
DOI: 10.1089/cmb.2007.0132